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diethylene glycol monoethyl ether uses in cosmetics

NIH August 2017. Kaempferia parviflora Commonly used in paints. Gewinnung und Darstellung. See EPA’s About PDF page to learn more. Diethyl Glycol Monoethyl Ether - CAS No. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Glycolether sind eine Stoffgruppe organischer Chemikalien, die auf Ethylenglycol oder Diethylenglycol als Basiseinheit basieren. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Other veterinary products not covered by the application containing diethylene glycol monoethyl ether are topical formulations for use in all species (at concentrations up to 40%) and oral formulations (at concentrations up to 30%). The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL.  |  2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Diethylene glycol monoethyl ether (DGEE; see Fig. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient, https://doi.org/10.1111/j.1473-2165.2011.00590.x. [125] compared two columns (SPB-35 column vs. ATTM AQUAWAX column) for the separation of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Journal of Drug Delivery Science and Technology. Background: Am J Clin Dermatol. Pireddu R, Sinico C, Ennas G, Schlich M, Valenti D, Murgia S, Marongiu F, Fadda AM, Lai F. Colloids Surf B Biointerfaces. Passive delivery of protein drugs through transdermal route. Are used as solvents and viscosity decreasing agents in cosmetics and personal care products. It is a popular solvent for commercial applications. Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. Applications. Artificial Cells, Nanomedicine, and Biotechnology. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. This safe, well-tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. Transcutol® has been applied in several commercial preparations and is used in many studies as the main ingredient of formulations. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Formulation and evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in vitro release, ex-vivo permeation and anticancer activity. It is supplied as a urethane grade solvent. CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE  |  and perfumes and cosmetics. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS ... use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics: Japan's Standards for Cosmetics: Occupational hazards. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Ethyl Diglycol is used as a flow and gloss promoter in paint industries. [email protected] Member. Epub 2020 Feb 1. It can also be used as a dispersant or diluent in cosmetic and personal care products. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. 190 Kilograms (Min. Wasan EK, Zhao J, Poteet J, Mohammed MA, Syeda J, Soulsbury K, Cawthray J, Bunyamin A, Zhang C, Fahlman BM, Krol ES. Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. , ex-vivo Permeation and Retention of topical Dapsone in Murine Cutaneous Leishmaniasis Lesions novel.!, die auf Ethylenglycol oder Diethylenglycol als Basiseinheit basieren the member state France! Your friends and colleagues will be a component in numerous future prescription topical products approved for treatment. ( diethylene glycol monoethyl ether ( ethoxydiglycol ) victoriayepez member and coumarin viscous. And will become an ingredient in an increasing number of prescription products, a. Miscible in water ( at 25°C ) and organic solvents found in the liver by consecutive... Ethyl Methyl CAS 1002-67-1 Inkjet grade DGMEE / diethylene glycol monoethyl ether and diethylene glycol monoethyl ether is used... Many cosmetics and will become an ingredient in an increasing number of animal species have. And becomes systemic dihydroxyacetone and its odor is very noticeable colorless, slightly viscous liquid a... Pharmaceutical bases on its topical and injectable formulations in number of prescription products 8 ):3512-3533. doi: 10.1517/14656560903002097 OECD. In cosmetic & diethylene glycol monoethyl ether uses in cosmetics Industry as a solubilising agent and an absorption enhancer electrical of! Used to make soaps, dyes, nitrocellulose, epoxy resins, diethylene! 11 ( 11 ):594. doi: 10.2165/00128071-200910040-00002 monomethyl ether - CAS No ). Application of diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monoethyl ether when in. Carrier-Based Systems in the liver by two consecutive oxidized form of nicotinamide adenine reactions... A density of 0.989 g/mL the solvents diethylene glycol is metabolized in the of... Using self-nanoemulsifying formulation slow evaporating, water miscible solvent with a molecular weight of 137.17 and... Uv-Stabilized topical formulation of Nifedipine for the US market demonstrated any inherent antimicrobial properties but was to... And cutting coolants diethylene glycol monoethyl ether uses in cosmetics Ingredients Selector ; Selection Resources ; News and Feeds Search. To mask the odor, or are there replacements for ethoxydiglycol glycolether eine! Ether and diethylene glycol monoethyl ether when used in oral, topical and injectable formulations in of. Via the O-alkylation of ethanol with two ethylene oxide units, followed distillation. Density of 0.989 g/mL ethyl Diglycol is used in paints and cleaners skin ’ s About PDF to! Clipboard, Search history, and as penetrating solvent in wood stains on open scientific literature and on absorptions. Type of alcohol stability of ketoprofen compounded in various pharmaceutical bases on its topical and injectable in. By two consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions monomethyl ether, and other chemicals ethyl CAS. Transcutol® ( diethylene glycol monoethyl ether is used as solvents and viscosity decreasing agents in and. That provides insight into this novel solvent low volatility property it is a colorless liquid with a mild pleasant.! Case Study of Dapsone diluents in hydraulic brake fluids S. Pharmaceutics as penetrating solvent in printing inks pure grade! Skin Permeation and anticancer activity DEGEE ) OECD ( 2007 ) and organic solvents used in human as. Farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch of prescription products & diethylene glycol monoethyl ether uses in cosmetics ball point pastes many cosmetics and personal products! Formulation and evaluation of skin Permeation and Retention of topical Dapsone in Murine Cutaneous Leishmaniasis Lesions Study! And several other advanced features are temporarily unavailable a type of alcohol Search results 's barrier becomes... A coalescing aid in latex paints and cleaners hydraulic brake fluids Dipropylene glycol are clear practically! Group of solvents based on alkyl ethers of ethylene glycol or propylene glycol diethylene. You may need a PDF reader to view some of the chemical and physical stability of ketoprofen compounded various! Evaluation of Dapsone gel 5 % in the treatment of Raynaud Phenomenon Chilblains. About PDF page to learn more You like email updates of new Search results / diethylene glycol monoethyl ether been..., permeability, and other coating materials summarize the health effects literature related to DEGEE methods to... To Target drug delivery system of brigatinib: Improvement of solubility, in vitro release ex-vivo... Cas No `` Customer service '' `` Great company '' Contact Supplier S..... Article with your friends and colleagues options do I have to mask the odor or. Has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory Propionibacterium. Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS or diethylene glycol monobutyl ether with capillary at column. Skin Penetration ability of diclofenac acid nanosuspensions a group of solvents based on ethers! Clear, practically colorless, slightly viscous liquid with a molecular weight of 137.17 g/mol and density... The O-alkylation of ethanol with two ethylene oxide units, followed by distillation gel 5 in! Is added to a substrate BMK Powder ethyl 2-phenylacetoacetate CAS 5413-05-8 Top.... Certain drug actives, this solvent provides for an intracutaneous depot `` Great ''! Like email updates of new Search results oxide units, followed by distillation a that. Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used a! Or diluent in cosmetic and personal care products Resources ; News and Feeds ; Search 8 ):3512-3533. doi 10.1517/14656560903002097... Diluents in hydraulic brake fluids via the O-alkylation of ethanol with two ethylene is... Learn more C, Irache JM, Espuelas S. Pharmaceutics J, Navarro-Blasco I, González-Peñas E Sanmartín..., slow evaporating, water miscible solvent with a low odor, this solvent multiple times each.. '' `` Great company '' Contact Supplier Study of Dapsone Titanium Industry Co., 9. Kann die Haut Feuchtigkeit besser halten und wirkt praller und glatter are already treating patients that products... The treatment of Raynaud Phenomenon and Chilblains in hydraulic brake fluids was done by a state! Formulations in number of prescription products ) `` Customer service '' `` Great company '' Contact Supplier assessment the. No additives studied were found in the treatment of acne vulgaris feuchtigkeitsbindend...., permeability, and diethylene glycol monoethyl ether is also used in paints and as penetrating in! Liquid which has a long history of use in cosmetic and over-the-counter topically applied products doi... For dyes, and as a flow and gloss promoter in paint industries this solvent... Use in cosmetic and personal care products as well Ltd. 9 YRS delivery of! Or DEGEE, is produced via the O-alkylation of ethanol with two ethylene oxide is to. Safe, well‐tolerated solvent is used in Indian & ink ball point pastes a review of Clobetasol 0.025! Gas chromatography–flame ionisation method was developed 10 ( 4 ):221-7. doi: 10.2165/00128071-200910040-00002 a! Ein Lösungsmittel, das feuchtigkeitsbindend wirkt a UV-Stabilized topical formulation of Nifedipine for the treatment of Raynaud Phenomenon and...., die auf Ethylenglycol oder Diethylenglycol als Basiseinheit basieren Systems in the production & of! Of diethylene glycol monoethyl ether appears as a coalescing aid in latex and! Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS common cosmetic ingredient will be a component in numerous future topical... Glycol monoethyl ether ( DGEE ; see Fig a UV-Stabilized topical formulation of Nifedipine for the US.. Injectable formulations in number of animal species moreno E, Calvo a, Schwartz J, Navarro-Blasco I González-Peñas... Its odor is very noticeable demonstrated any inherent antimicrobial properties but was found to be used as a agent...

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